Gut Commensal Immunomodulatory Factors: Identification and Structure‐Function Studies

Gut commensal flora: tolerance and homeostasis

Commensal microorganisms are not ignored by the intestinal immune system. Recent evidence shows that commensals actively participate in maintaining intestinal immune homeostasis by interacting with intestinal epithelial cells and delivering tolerogenic signals that are transmitted to the underlying cells of the immune system.

Commensal gut bacteria: mechanisms of immune modulation.

Mucosal immune responses to pathogenic gut bacteria and the mechanisms that govern disease progression and outcome have been researched intensely for decades. More recently, the influence of the resident non-pathogenic or 'commensal' microflora on mucosal immune function and gut health has emerged as an area of scientific and clinical importance. Major differences occur in the mucosal immune re...

Commensal gut bacteria and the etiopathogenesis of rheumatoid arthritis.

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Microbiology. The thin line between gut commensal and pathogen.

Depletion of gut commensal bacteria attenuates intestinal ischemia/reperfusion injury.

Gut commensal bacteria play important roles in the development and homeostasis of intestinal immunity. However, the role of gut commensals in intestinal ischemia/reperfusion (I/R) injury is unclear. To determine the roles of gut commensal bacteria in intestinal IR injury, we depleted gut microbiota with a broad-spectrum antibiotic cocktail and performed mesenteric I/R (M I/R). First, we confirm...